Lauréats de l’appel à projets "Grants scientifiques 2022"

En janvier 2022, la Fondation contre le Cancer a lancé son appel biannuel « Grants scientifiques 2022 » en recherche fondamentale, translationnelle & clinique et dans la recherche relative aux cancers liés à l’exposition à l’amiante. 
Grâce à la générosité de ses donateurs, la Fondation contre le Cancer finance cette année 57 projets provenant de diverses institutions de recherche en oncologie du pays, pour un montant total de 25,7 millions d'euros.  Ces projets visent à mieux comprendre la maladie, augmenter encore les chances de guérison et améliorer la qualité de vie des personnes atteintes d'un cancer. 
Le financement de la recherche scientifique belge en cancérologie est la mission prioritaire de la Fondation contre le Cancer et ce depuis plus de 30 ans.  En finançant les recherches les plus innovantes contre le cancer nous contribuons à transformer l'espoir en victoire.

Les lauréats sélectionnés par les conseils scientifiques indépendants sont les suivants : 

 

Recherche fondamentale : 29 projets - € 14 294 198

Equipes de recherche

Organisations

Montant

Titre du projet

 

Agostinis Patrizia KU Leuven €350.00 Harnessing lysosomal iron homeostasis to prevent melanoma dissemination PLUS D’INFOS
Beck Benjamin ULB €598.00 A cellular reservoir for metaplasia and cancer initiation in the oesophagus PLUS D’INFOS
Callewaert Nico UGent €360.00 Arming therapeutic CAR-T cells with glyco-engineered suppressors of tumor-infiltrating regulatory T cells. PLUS D’INFOS
Constantinescu Stefan Institut de Duve €600.00 Role of the Human Thrombopoietin Receptor in Myeloproliferative Neoplasms and transition to Secondary Acute Myeloid Leukemia. PLUS D’INFOS
Cools Jan KU Leuven €540.00 EZH2 as a transcriptional activator in T-ALL PLUS D’INFOS
Corbet Cyril UCLouvain €580.00 Towards metabolic targeting of the minimal residual disease in head and neck cancers PLUS D’INFOS
De Smet Frederik & Vermeirssen Vanessa & Quintens Roel KU Leuven &UGent & Belgian Nucleair Research Centre €480.00 Targeting radiation-induced plasticity in Glioblastoma: from fundamental insights to tailored therapeutic opportunities PLUS D’INFOS
Dierickx Daan KU Leuven €400.00 Molecular characterization of hyperactive T cell receptor signaling in peripheral T cell lymphoma to uncover druggable targets PLUS D’INFOS
Elewaut Dirk UGent €475.00 Role of endogenous NKT ligands induced by Endoplasmic Reticulum stress in NASH-driven hepatocellular carcinoma PLUS D’INFOS
Elia Ilaria KU Leuven €336.00 Potentiating the metabolic fitness of metastasis associated CD8+ T cells through spatial metabolomics. PLUS D’INFOS
Fendt Sarah-Maria KU Leuven €600.00 Lipid metabolism in obesity and aging-induced cancer metastasis PLUS D’INFOS
Gilles Christine ULiège €360.00 Studying Tissue Factor-dependent membrane protein proteolysis in metastasis PLUS D’INFOS
Goossens Steven UGent €480.00 Oncogenic Role of SOX11 in T-cell acute lymphoblastic leukemia PLUS D’INFOS
Goriely Stanislas ULB €478.40 Targeting Heme Oxygenase-1 expressing tumor associated macrophages to improve cancer immunotherapy PLUS D’INFOS
Gurzov Esteban & Verslype Chris & Scott Charlotte ULB & KU Leuven & UGent €480.00 Obesity-associated Hepatocellular Carcinoma at Single Cell Resolution for Risk Prediction and Novel Therapeutics - HepatoSCRIPT PLUS D’INFOS
Marine Jean-Christophe KU Leuven €600.00 Detection and prevention of early metastatic dissemination of melanoma PLUS D’INFOS
Mestdagh Pieter UGent €510.00 Identifying lncRNA modulators of T-cell activation to enhance immune-checkpoint inhibition therapy PLUS D’INFOS
Movahedi Kiavash VUB €478.00 Macrophage-based cell therapy for brain cancer PLUS D’INFOS
Noel Agnès ULiège €600.00 Targeting ferroptosis resistance of metastasizing cancer cells in lymph node PLUS D’INFOS
Pastushenko Ievgenia ULB €600.00 Defining the role of the frequently mutated epigenetic regulators in cancer PLUS D’INFOS
Rooman Ilse & Van Laethem Jean-Luc VUB & ULB €476.80 InterCePPT: Interfere with Cellular Positioning in the Pancreatic Tumor PLUS D’INFOS
Speleman Franki UGent €600.00 Single-cell and spatial multi-omics exploration of tumor intrinsic and microenvironment responses to ALK-ATR-CHK1-RRM2 axis drugging in neuroblastoma PLUS D’INFOS
Tissir Fadel UCLouvain €600.00 Glioblastoma prognosis and treatment: Could DIAPH3 be a game-changer? PLUS D’INFOS
van der Bruggen Pierre Institut de Duve €360.00 Cancer-associated neutrophils and their impact on immune cells PLUS D’INFOS
Van Keymeulen Alexandra ULB €369.60 Deciphering the cell plasticity preceding tumor appearance in the mammary gland PLUS D’INFOS
van Loo Geert UGent €480.00 The impact of cell death on the cancer stem cell niche in non-melanoma skin cancer PLUS D’INFOS
Van Vlierberghe Pieter UGent €600.00 PU.1 as driver of leukemic stem cells in human T cell acute lymphoblastic leukemia PLUS D’INFOS
Vanden Berghe Tom UAntwerpen €462.40 Studying the epigenetic regulation of ferroptosis in high-risk neuroblastoma PLUS D’INFOS
Vleminckx Kris UGent €440.00 CRISPR-mediated mapping of genetic dependencies in well-differentiated and dedifferentiated liposarcoma PLUS D’INFOS

 

Recherche translationnelle et clinique : 21 projets - € 9 557 935

Equipes de recherche

Organisations

Montant

Titre du projet

 

Baron Frédéric & Humblet-Baron Stephanie & Marchant Arnaud ULiège & KU Leuven & ULB €600.00 Systems Vaccinology in allogeneic hematopoietic stem cell transplant recipients PLUS D’INFOS
Blanpain Cédric ULB €600.00 Defining and targeting tumor cell states responsible for resistance to therapy PLUS D’INFOS
Buisseret Laurence ULB €300.00 Impact of immunotherapy on triple-negative breast cancer microenvironement PLUS D’INFOS
Ceelen Wim & Van Ginderachter Jo UGent & VUB €512.50 Engineering the tumor immune microenvironment in colorectal peritoneal metastases by locoregional delivery of toll like receptor agonists PLUS D’INFOS
De Geest Bruno & Laoui Damya UGent & VUB €450.00 A translational cancer vaccination approach based on co-delivery of tumor antigen and Toll-like receptor agonists PLUS D’INFOS
De Moerloose Barbara UGent €300.00 Integration of genome, epigenome, and transcriptome in juvenile myelomonocytic leukemia and functional analysis of circular RNAs as novel biomarker and/or therapeutic targets. PLUS D’INFOS
De Preter Katleen UGent €588.24 NIPITplus, a multi-cancer blood test to predict immune checkpoint inhibitor response and monitor toxicity PLUS D’INFOS
De Wever Olivier UGent €400.00 Exploiting patient-derived models to guide therapeutic decision making in soft tissue sarcoma PLUS D’INFOS
Desmedt Christine KU Leuven €598.97 MetLob: A post-mortem tissue donation study dedicated to Metastatic Lobular breast cancer PLUS D’INFOS
Flamen Patrick Institut Jules Bordet €299.35 Lu-177-FAPI (fibroblast activation protein inhibitor) radioligand therapy in colorectal and pancreatic cancers: Phase 1 study based on dosimetric rationale PLUS D’INFOS
Jacobs Sandra BSPHO €400.00 Prospective international phase-III trials to improve treatment effectiveness and quality of survival in children with embryonal brain tumours PLUS D’INFOS
Lambrecht Maarten & De Saint Hubert Marijke KU Leuven & SCK-CEN €523.05 ProPOSE: Proton therapy in Pregnancy for Optimal, Safe and Effective cancer treatment PLUS D’INFOS
Michaux Lucienne UZ Leuven €448.28 Improved Cytogenomic Diagnosis in Lymphoma: Opportunities of Optical Genome Mapping and Long-read Sequencing PLUS D’INFOS
Nuyts Sandra & Nevens Daan UZ Leuven & UZ Antwerpen €400.00 PROLoNg-trial: Pembrolizumab and Radiotherapy for OLigometastatic squamous cell carcinoma of the head and Neck cancer: a randomized phase III study PLUS D’INFOS
Peeters Marc & Verslype Chris UZ Antwerpen & KU Leuven €549.87 Impact of ccfDNA on clinical decision making in NEN patients PLUS D’INFOS
Saussez Sven & Verset Laurine Université de Mons & Institut Jules Bordet €239.68 Development of a targeted theranostic platform combining magnetic nanoparticles and radiotherapy for head and neck cancer treatment PLUS D’INFOS
Sotiriou Christos ULB €600.00 Decoding metastatic breast cancer heterogeneity using spatial transcriptomics and AI in the AURORA study PLUS D’INFOS
Tejpar Sabine KU Leuven €449.50 Using mucins as friends in colorectal cancer diagnostics and treatment PLUS D’INFOS
Van den Eynde Marc UCLouvain €249.50 Dimensional characterization of immune and T cells population in metastatic colorectal cancer for the development of circulating immune biomarker. PLUS D’INFOS
Van der Veken Pieter UAntwerpen €450.00 Diagnostic and theranostic targeting of fibroblast activation protein (FAP) with gold nanoparticles decorated with FAPIs and FAPI fragments. PLUS D’INFOS
Veldeman Liv & Remouchamps Vincent UGent & CHU UCL Namur €599.00 Prolonged abdominal deep-inspiration breath hold: clinical translation, monitoring and assessment of cardiac and lung toxicity reduction in prone crawl radiotherapy of breast cancer PLUS D’INFOS

 

Amiante : 7 projets - € 1 943 370 

Equipes de recherche

Organisations

Montant

Titre du projet

 

Bisteau Xavier ULB €245.00 Exploiting the sensitivity of malignant pleural mesothelioma to CDK4 inhibitory drugs PLUS D’INFOS
Cataldo Didier ULiège €200.00 CCL5-CCR5 axis: a therapeutic target in cisplatin resistant mesothelioma? PLUS D’INFOS
Gevaert Kris & Lamote Kevin UGent & UAntwerpen €249.35 Validation of a protein biomarker panel in exhaled breath condensate PLUS D’INFOS
Huaux François UCLouvain €313.60 Syndecan-1-expressing macrophages: a new immunosuppressive entity in fibre-induced cancer PLUS D’INFOS
Meylan Etienne ULB €375.42 Analyses of the tumor immune compartment and tumor-associated neutrophils in new generation mouse models of malignant mesothelioma PLUS D’INFOS
Willems Luc ULiège €240.00 Eosinophils propel extracellular traps on mesothelioma cells and inhibit chemoimmunotherapy PLUS D’INFOS
Zhu Jingjing Institut de Duve €320.00 Regulation of anti-tumor immunity by the aryl hydrocarbon receptor in asbestos-induced mesothelioma PLUS D’INFOS

 

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